Permanent cilia loss during cerebellar granule cell neurogenesis involves withdrawal of cilia maintenance and centriole capping

Abstract excerpt

Brain neurons utilize the primary cilium as a privileged compartment to detect and respond to extracellular ligands such as Sonic hedgehog (SHH). However, cilia in cerebellar granule cell (GC) neurons disassemble during differentiation through ultrastructurally unique intermediates, a process we refer to as cilia deconstruction. In addition, mature neurons do not reciliate despite having docked centrioles. Here,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Fetal and Pediatric Neurological Disorders
• Share to Genetic and Kidney Cyst Diseases
• Share to Hedgehog Signaling Pathway Studies