Article

CEP78 functions downstream of CEP350 to control biogenesis of primary cilia by negatively regulating CP110 levels

2020-10-05

Abstract excerpt

CEP78 is a centrosomal protein implicated in ciliogenesis and ciliary length control, and mutations in the CEP78 gene cause retinal cone-rod dystrophy associated with hearing loss. However, the mechanism by which CEP78 affects cilia formation is unknown. Based on a recently discovered disease-causing CEP78 p.L150S mutation, we identified the disease-relevant interactome of CEP78. We confirmed that CEP78 interact...

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Literature Corpus work: 1b948732-d1b0-5933-8ab6-0d1af13ab899
DOI: 10.1101/2020.10.05.325936

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