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Article

Break-induced replication requires all essential DNA replication factors except those specific for pre-RC assembly.

Genes & development - 1 Jun 2010

Lydeard John R, Lipkin-Moore Zachary, Sheu Yi-Jun, Stillman Bruce, Burgers Peter M, Haber James E

Abstract excerpt

Break-induced replication (BIR) is an efficient homologous recombination (HR) pathway employed to repair a DNA double-strand break (DSB) when homology is restricted to one end. All three major replicative DNA polymerases are required for BIR, including the otherwise nonessential Pol32 subunit. Here we show that BIR requires the replicative DNA helicase (Cdc45, the GINS, and Mcm2-7 proteins) as well as Cdt1. In...

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Source

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Identifiers

PMID: 20516198
DOI: 10.1101/gad.1922610
PMCID: PMC2878651

Genes

PCNA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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