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CYP2D6*10 polymorphism and the enantioselective O-desmethylation of S-(+)- and R-(-)-venlafaxine in Japanese psychiatric patients.

Basic & clinical pharmacology & toxicology - 1 May 2021

Sasaki Taro, Yasui-Furukori Norio, Komahashi-Sasaki Hazuki, Shinozaki Masataka, Hayashi Yuki, Kato Kazuko, Inoue Yoshimasa, Tsuchimine Shoko, Watanabe Takashi, Sugawara Norio, Shimoda Kazutaka

Abstract excerpt

According to previous studies, R-(-)-venlafaxine (VEN) has higher enantioselectivity than S-(+)-VEN, and the plasma concentration of R-(-)-VEN varies depending on CYP2D6 activity. Therefore, we examined the pharmacokinetic effects of CYP2D6*10 genotypes on the steady-state concentrations of the enantiomers of VEN. The individuals were 71 Japanese depressed patients treated with racemic VEN. The concentrations of...

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Identifiers

PMID: 33470005
DOI: 10.1111/bcpt.13560

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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