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Article

The Influence of Combined CYP2D6 and CYP2C19 Genotypes on Venlafaxine and O-Desmethylvenlafaxine Concentrations in a Large Patient Cohort.

Journal of clinical psychopharmacology - 1 Jan 2000

Kringen Marianne K, Bråten Line S, Haslemo Tore, Molden Espen

Abstract excerpt

PURPOSE: The antidepressant venlafaxine is largely O-desmethylated by CYP2D6, whereas CYP2C19 mediates an alternative metabolic route of venlafaxine through N-desmethylation. The aim of this study was to investigate the combined effect of genotype-predicted CYP2D6 and CYP2C19 phenotypes on serum concentrations of venlafaxine and metabolites in a large patient population. METHODS: Patients were retrospectively...

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PMID: 32134850
DOI: 10.1097/JCP.0000000000001174

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