Article
Cerebellar purkinje cell dysfunction contributes to gait impairments in Shank3-mutant mice.
Molecular autism - 31 Jan 2026
Liu Haiying, Huang Xin, Ma Guaiguai, Zhao Xin, Xia Ruixin, Li Zimeng, Guo Baolin, Wu Shengxi, Wang Wenting
Abstract excerpt
BACKGROUND: Complex motor dysfunction is a common comorbidity of autism spectrum disorder (ASD) and may be attributed to the perturbation of cerebellar function. Purkinje cells (PCs), which serve as the primary output neurons of the cerebellum, are integral to various aspects of cerebellar motor function, such as gait control. However, the specific contribution of PCs to ASD has not been fully characterized....
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