Article
Biological constraints on GWAS SNPs at suggestive significance thresholds reveal additional BMI loci.
eLife - 18 Jan 2021
Hammond Reza K, Pahl Matthew C, Su Chun, Cousminer Diana L, Leonard Michelle E, Lu Sumei, Doege Claudia A, Wagley Yadav, Hodge Kenyaita M, Lasconi Chiara, Johnson Matthew E, Pippin James A, Hankenson Kurt D, Leibel Rudolph L, Chesi Alessandra, Wells Andrew D, Grant Struan Fa
Abstract excerpt
To uncover novel significant association signals (p<5×10-8), genome-wide association studies (GWAS) requires increasingly larger sample sizes to overcome statistical correction for multiple testing. As an alternative, we aimed to identify associations among suggestive signals (5 × 10-8≤p<5×10-4) in increasingly powered GWAS efforts using chromatin accessibility and direct contact with gene promoters as biological...
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