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Article

Smad3 deficiency promotes beta cell proliferation and function in db/db mice via restoring Pax6 expression

1 Jan 2021

Abstract excerpt

Taken together, we discovered a pathogenic role of Smad3 in beta cell loss and dysfunction via targeting the protective Pax6. Thus, Smad3 may represent as a novel therapeutic target for type 2 diabetes prevention and treatment.

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Identifiers

PMID: 33456576
DOI: 10.7150/thno.51857

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