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Article

Identification of Smad3-related transcriptomes in type-2 diabetic nephropathy by whole transcriptome RNA sequencing.

Journal of cellular and molecular medicine - 1 Feb 2021

Zhou Qin, Guo Honghong, Yu Chaolun, Huang Xiao-Ru, Liang Liying, Zhang Puhua, Yu Jianwen, Zhang Jizhou, Chan Ting-Fung, Ma Ronald C W, Lan Hui-Yao

Abstract excerpt

Smad3 deficiency prevents the development of type 2 diabetic nephropathy; however, the underlying molecular mechanisms remain unknown. In this study, we aimed to identify Smad3-related genes involved in the pathogenesis of diabetic kidney disease. High-throughput RNA sequencing was performed to profile the whole transcriptome in the diabetic kidney of Smad3 WT-db/db, Smad3 KO-db/db, Smad3+/- db/db and their...

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Identifiers

PMID: 33369170
DOI: 10.1111/jcmm.16133
PMCID: PMC7882931

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