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Article

Fine-mapping of the non-coding variation driving the Caucasian LRRK2 GWAS signal in Parkinson's disease.

Parkinsonism & related disorders - 1 Feb 2021

Heckman Michael G, Labbé Catherine, Kolicheski Ana L, Soto-Beasley Alexandra I, Walton Ronald L, Valentino Rebecca R, Brennan Emily R, Johnson Patrick W, Baheti Saurabh, Sarangi Vivekananda, Ren Yingxue, Uitti Ryan J, Wszolek Zbigniew K, Ross Owen A

Abstract excerpt

INTRODUCTION: Genome-wide association studies (GWAS) have confirmed the leucine-rich repeat kinase 2 (LRRK2) gene as a susceptibility locus for idiopathic Parkinson's disease (PD) in Caucasians. Though the rs1491942 and rs76904798 variants have shown the strongest associations, the causal variant(s) remains unresolved. Therefore, the aim of this study was to identify variants that may be driving the LRRK2 GWAS...

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Identifiers

PMID: 33454605
DOI: 10.1016/j.parkreldis.2020.12.016
PMCID: PMC9310432

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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