Fine-mapping, gene expression and splicing analysis of the disease associated LRRK2 locus.

doi:10.1371/journal.pone.0070724

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Article

Fine-mapping, gene expression and splicing analysis of the disease associated LRRK2 locus.

PloS one - 1 Jan 2013

Trabzuni Daniah, Ryten Mina, Emmett Warren, Ramasamy Adaikalavan, Lackner Karl J, Zeller Tanja, Walker Robert, Smith Colin, Lewis Patrick A, Mamais Adamantios, de Silva Rohan, Vandrovcova Jana, Hernandez Dena, Nalls Michael A, Sharma Manu, Garnier Sophie, Lesage Suzanne, Simon-Sanchez Javier, Gasser Thomas, Heutink Peter, Brice Alexis, Singleton Andrew, Cai Huaibin, Schadt Eric, Wood Nicholas W, Bandopadhyay Rina, Weale Michael E, Hardy John, Plagnol Vincent

Abstract excerpt

Association studies have identified several signals at the LRRK2 locus for Parkinson's disease (PD), Crohn's disease (CD) and leprosy. However, little is known about the molecular mechanisms mediating these effects. To further characterize this locus, we fine-mapped the risk association in 5,802 PD and 5,556 controls using a dense genotyping array (ImmunoChip). Using samples from 134 post-mortem control adult...

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PMID: 23967090
DOI: 10.1371/journal.pone.0070724
PMCID: PMC3742662

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