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ADRA2A promotes the classical/progenitor subtype and reduces disease aggressiveness of pancreatic cancer

12 Aug 2024

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) manifests diverse molecular subtypes, including the classical/progenitor and basal-like/squamous subtypes, with the latter known for its aggressiveness. We employed integrative transcriptome and metabolome analyses to identify potential genes contributing to the molecular subtype differentiation and its metabolic features. Our comprehensive analysis revealed that...

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PMID: 39136088
DOI: 10.1093/carcin/bgae056

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