Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Canonical and non-canonical functions of p53 isoforms: potentiating the complexity of tumor development and therapy resistance

12 Jun 2024

Abstract excerpt

Full-length p53 (p53α) plays a pivotal role in maintaining genomic integrity and preventing tumor development. Over the years, p53 was found to exist in various isoforms, which are generated through alternative splicing, alternative initiation of translation, and internal ribosome entry site. p53 isoforms, either C-terminally altered or N-terminally truncated, exhibit distinct biological roles compared to p53α,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Epigenetics and DNA Methylation
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38866752
DOI: 10.1038/s41419-024-06783-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 19 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Canonical and non-canonical functions of p53 isoforms: potentiating the complexity of tumor development and therapy resistancePMID 38866752Read ↗

Uncovering the role of p53 splice variants in human malignancy: a clinical perspectiveSemantic proximity Read ↗

Role of p53 isoforms and aggregations in cancerSemantic proximity Read ↗

The Emerging Landscape of p53 Isoforms in Physiology, Cancer and Degenerative Diseases.Semantic proximity Read ↗

The Δ133p53 Isoforms, Tuners of the p53 PathwaySemantic proximity Read ↗

p53 Isoforms as Cancer Biomarkers and Therapeutic TargetsSemantic proximity Read ↗

The role of truncated p53 isoforms in the DNA damage responseSemantic proximity Read ↗

p53 Family: Role of Protein Isoforms in Human CancerSemantic proximity Read ↗

Biological functions of p53 isoforms through evolution: lessons from animal and cellular models.Semantic proximity Read ↗

p53 Isoforms: An Intracellular Microprocessor?Semantic proximity Read ↗

p53 Family isoforms.Semantic proximity Read ↗

Combining TP53 mutation and isoform has the potential to improve clinical practice.Semantic proximity Read ↗

p53 isoforms gain functionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.