Article
The Emerging Landscape of p53 Isoforms in Physiology, Cancer and Degenerative Diseases.
International journal of molecular sciences - 11 Dec 2019
Anbarasan Thineskrishna, Bourdon Jean-Christophe
Abstract excerpt
p53, first described four decades ago, is now established as a master regulator of cellular stress response, the "guardian of the genome". p53 contributes to biological robustness by behaving in a cellular-context dependent manner, influenced by several factors (e.g., cell type, active signalling pathways, the type, extent and intensity of cellular damage, cell cycle stage, nutrient availability, immune...
Topics
- Animals
- Conserved Sequence
- Humans
- Mutation
- Neoplasms
- Physiological Phenomena
- Protein Isoforms
- Tumor Suppressor Protein p53