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p53 Isoforms in Cellular Senescence- and Ageing-Associated Biological and Physiological Functions

29 Nov 2019

Abstract excerpt

Cellular senescence, a term originally used to define the characteristics of normal human fibroblasts that reached their replicative limit, is an important factor for ageing, age-related diseases including cancer, and cell reprogramming. These outcomes are mediated by senescence-associated changes in gene expressions, which sometimes lead to the secretion of pro-inflammatory factors, or senescence-associated...

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PMID: 31795382
DOI: 10.3390/ijms20236023

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