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Article

p53 and its isoforms in DNA double-stranded break repair

17 May 2019

Abstract excerpt

DNA double-stranded break (DSB) is one of the most catastrophic damages of genotoxic insult. Inappropriate repair of DNA DSBs results in the loss of genetic information, mutation, and the generation of harmful genomic rearrangements, which predisposes an organism to immunodeficiency, neurological damage, and cancer. The tumor repressor p53 plays a key role in DNA damage response, and has been found to be mutated...

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PMID: 31090271
DOI: 10.1631/jzus.b1900167

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