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Article

Germline MC1R variants and frequency of somatic BRAF, NRAS, and TERT mutations in melanoma: Literature review and meta-analysis.

Molecular carcinogenesis - 1 Mar 2021

Zanna Ines, Caini Saverio, Raimondi Sara, Saieva Calogero, Masala Giovanna, Massi Daniela, Cocorocchio Emilia, Queirolo Paola, Stanganelli Ignazio, Gandini Sara

Abstract excerpt

Germline variants of the melanocortin-1-receptor (MC1R) gene are the most common genetic trait predisposing to cutaneous melanoma (CM). Here, we performed a literature review and meta-analysis of the association between MC1R gene variants and the frequency of somatic mutations of the BRAF, NRAS, and TERT genes in CM patients. We included studies published until January 2020 in MEDLINE, EMBASE, Ovid Medline, and...

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PMID: 33444485
DOI: 10.1002/mc.23280

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