Article
Heterogeneity of BRAF, NRAS, and TERT Promoter Mutational Status in Multiple Melanomas and Association with MC1R Genotype: Findings from Molecular and Immunohistochemical Analysis.
The Journal of molecular diagnostics : JMD - 1 Jan 2018
Pellegrini Cristina, Di Nardo Lucia, Cipolloni Gianluca, Martorelli Claudia, De Padova Marina, Antonini Ambra, Maturo Maria Giovanna, Del Regno Laura, Strafella Sara, Micantonio Tamara, Leocata Pietro, Peris Ketty, Fargnoli Maria Concetta
Abstract excerpt
Data on somatic heterogeneity and germline-somatic interaction in multiple primary melanoma (MPM) patients are limited. We investigated the mutational status of BRAF, NRAS, and TERT promoter genes in 97 melanomas of 44 MPM patients and compared molecular and immunohistochemical findings. We further evaluated the association of somatic alterations with the germline MC1R genotype. Mutations in BRAF gene were...
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