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Article

SEX IN THE 90s:<i>SRY</i>and the Switch to the Male Pathway

1 Oct 1998

Abstract excerpt

In mammals the male sex determination switch is controlled by a single gene on the Y chromosome, SRY. SRY encodes a protein with an HMG-like DNA-binding domain, which probably acts as a local organizer of chromatin structure. It is believed to regulate downstream genes in the sex determination cascade, although no direct targets of SRY are clearly known. More genes in the pathway have been isolated through...

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Identifiers

PMID: 9558474
DOI: 10.1146/annurev.physiol.60.1.497

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Source receipt: pubmed, retrieved 7 Sept 2026.

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