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Article

Chronic inflammatory state in sickle cell anemia patients is associated with HBB(*)S haplotype.

Cytokine - 1 Feb 2014

Bandeira Izabel C J, Rocha Lillianne B S, Barbosa Maritza C, Elias Darcielle B D, Querioz José A N, Freitas Max Vitor Carioca, Gonçalves Romélia P

Abstract excerpt

The chronic inflammatory state in sickle cell anemia (SCA) is associated with several factors such as the following: endothelial damage; increased production of reactive oxygen species; hemolysis; increased expression of adhesion molecules by leukocytes, erythrocytes, and platelets; and increased production of proinflammatory cytokines. Genetic characteristics affecting the clinical severity of SCA include...

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Source

Identifiers

PMID: 24290434
DOI: 10.1016/j.cyto.2013.10.009

Genes

HBB
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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