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Article

Inborn errors of regulatory T-cell differentiation and function.

The Journal of allergy and clinical immunology - 1 Dec 2025

Oktelik Fatma Betul, Luo Ying, Benamar Mehdi, Chatila Talal A

Abstract excerpt

Regulatory T (Treg) cells play an essential role in enforcing peripheral immune tolerance and promoting tissue homeostasis and repair. Our understanding of their pivotal role in immune regulation has critically benefited from the identification of a growing number of inborn errors of immunity known as Tregopathies, which target different pathways governing Treg cell biology. The resulting disorders associated...

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Source

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Identifiers

PMID: 40633593
DOI: 10.1016/j.jaci.2025.07.001
PMCID: PMC12320740

Genes

BACH2
CTLA4
DEF6
FOXP3
IL2RA
IL2RB
LRBA
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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