Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Compound C exerts a therapeutic effect on Graves' orbitopathy via AMPK‑independent pathways

21 Mar 2025

Abstract excerpt

Compound C is an adenosine monophosphate‑activated protein kinase (AMPK) inhibitor, which is also recognized as a broad‑spectrum kinase inhibitor with anti‑proliferative effects. The present study investigated the therapeutic effects of a high concentration of compound C on Graves' orbitopathy (GO) pathogenesis beyond the AMPK‑dependent pathway using human orbital fibroblasts. Orbital connective tissue was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomedical Research and Pathophysiology
Share to Cancer Treatment and Pharmacology
Share to Ophthalmology and Eye Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40116114
DOI: 10.3892/ijmm.2025.5524

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Compound C exerts a therapeutic effect on Graves' orbitopathy via AMPK‑independent pathwaysPMID 40116114Read ↗

MicroRNA-27 inhibits adipogenic differentiation in orbital fibroblasts from patients with Graves’ orbitopathySemantic proximity Read ↗

Adenosine monophosphate-activated protein kinase activator inhibits activation of fibroblast-like synoviocytes but promotes hyaluronan and proteoglycan link protein 1 secretionSemantic proximity Read ↗

Functionally enhanced placenta-derived mesenchymal stem cells inhibit adipogenesis in orbital fibroblasts with Graves’ ophthalmopathySemantic proximity Read ↗

Independent adipogenic and contractile properties of fibroblasts in Graves' orbitopathy: an in vitro model for the evaluation of treatments.Semantic proximity Read ↗

The Orbital Fibroblast: A Key Player and Target for Therapy in Graves’ OphthalmopathySemantic proximity Read ↗

Activating AMP-activated protein kinase by an α1 selective activator compound 13 attenuates dexamethasone-induced osteoblast cell death.Semantic proximity Read ↗

TGFβ Treated Placenta Derived Mesenchymal Stem Cells Selectively Promote Anti-Adipogenesis in Thyroid-Associated OphthalmopathySemantic proximity Read ↗

PPAR-γ/PCK1 metabolic pathway modulate synovitis and fibrosis in KOA ratsSemantic proximity Read ↗

PPP2CA Drives Chondrocyte Metabolic Disorders and Underpins Osteoarthritis Pathogenesis through Targeting AMPK DephosphorylationSemantic proximity Read ↗

Butyrate Ameliorates Graves' Orbitopathy Through Regulating Orbital Fibroblast Phenotypes and Gut Microbiota.Semantic proximity Read ↗

AICAR and compound C negatively modulate HCC-induced primary human hepatic stellate cell activation in vitro.Semantic proximity Read ↗

Formononetin Suppresses Interleukin-6 Production in Lipopolysaccharide-Stimulated Macrophages Via Activation of the AMP-Activated Protein KinaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.