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Article

p53 haploinsufficiency and increased mTOR signalling define a subset of aggressive hepatocellular carcinoma

29 Jul 2020

Abstract excerpt

BACKGROUND & AIMS: p53 mutations occur frequently in human HCC. Activation of the mammalian target of rapamycin (mTOR) pathway is also associated with HCC. However, it is still unknown whether these changes together initiate HCC and can be targeted as a potential therapeutic strategy. METHODS: We generated mouse models in which mTOR was hyperactivated by loss of tuberous sclerosis complex 1 (Tsc1) with or without...

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PMID: 32738450
DOI: 10.1016/j.jhep.2020.07.036

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