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Article

AMPK-dependent and independent effects of AICAR and compound C on T-cell responses.

Oncotarget - 7 Jun 2016

Rao Enyu, Zhang Yuwen, Li Qiang, Hao Jiaqing, Egilmez Nejat K, Suttles Jill, Li Bing

Abstract excerpt

As a master metabolic sensor, AMP-activated protein kinase (AMPK) is involved in different fundamental cellular processes. Regulation of AMPK activity either by agonists (e.g., AICAR) or by antagonists (e.g., Compound C) has been widely employed to study the physiological functions of AMPK. However, mounting evidence indicates AMPK-independent effects for these chemicals and how they regulate immune cell...

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Identifiers

PMID: 27177226
DOI: 10.18632/oncotarget.9277
PMCID: PMC5085118

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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