Article
PRAS40 prevents development of diabetic cardiomyopathy and improves hepatic insulin sensitivity in obesity.
EMBO molecular medicine - 1 Jan 2014
Völkers Mirko, Doroudgar Shirin, Nguyen Nathalie, Konstandin Mathias H, Quijada Pearl, Din Shabana, Ornelas Luis, Thuerauf Donna J, Gude Natalie, Friedrich Kilian, Herzig Stephan, Glembotski Christopher C, Sussman Mark A
Abstract excerpt
Diabetes is a multi-organ disease and diabetic cardiomyopathy can result in heart failure, which is a leading cause of morbidity and mortality in diabetic patients. In the liver, insulin resistance contributes to hyperglycaemia and hyperlipidaemia, which further worsens the metabolic profile. Defects in mTOR signalling are believed to contribute to metabolic dysfunctions in diabetic liver and hearts, but evidence...
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