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Article

Hexokinase-II positively regulates glucose starvation-induced autophagy through TORC1 inhibition.

Molecular cell - 20 Feb 2014

Roberts David J, Tan-Sah Valerie P, Ding Eric Y, Smith Jeffery M, Miyamoto Shigeki

Abstract excerpt

Hexokinase-II (HK-II) catalyzes the first step of glycolysis and also functions as a protective molecule; however, its role in protective autophagy has not been determined. Results showed that inhibition of HK-II diminished, while overexpression of HK-II potentiated, autophagy induced by glucose deprivation in cardiomyocyte and noncardiomyocyte cells. Immunoprecipitation studies revealed that HK-II binds to and...

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Source

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Identifiers

PMID: 24462113
DOI: 10.1016/j.molcel.2013.12.019
PMCID: PMC3943874

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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