Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structural and functional polarisation of human pancreatic beta cells in islets from organ donors with and without type 2 diabetes.

Diabetologia - 1 Mar 2021

Cottle Louise, Gan Wan Jun, Gilroy Ian, Samra Jaswinder S, Gill Anthony J, Loudovaris Thomas, Thomas Helen E, Hawthorne Wayne J, Kebede Melkam A, Thorn Peter

Abstract excerpt

AIMS/HYPOTHESIS: We hypothesised that human beta cells are structurally and functional polarised with respect to the islet capillaries. We set out to test this using confocal microscopy to map the 3D spatial arrangement of key proteins and live-cell imaging to determine the distribution of insulin granule fusion around the cells. METHODS: Human pancreas samples were rapidly fixed and processed using the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytoplasmic Granules
Share to Insulin-Secreting Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insulin Secretion

Share to Islets of Langerhans

Share to Microscopy, Confocal

Share to Secretory Vesicles

Share to Tissue Culture Techniques

Share to Tissue Donors

Source

Open in PubMed Open full text

Identifiers

PMID: 33399909
DOI: 10.1007/s00125-020-05345-8
PMCID: PMC7864831

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural and functional polarisation of human pancreatic beta cells in islets from organ donors with and without type 2 diabetes.PMID 33399909Read ↗

Glucagon and GLP-1 Accelerate Pseudo-Islet Assembly and Unmask Sex-Specific Islet Fragmentation DynamicsSemantic proximity Read ↗

Molecular and functional profiling of human islets: from heterogeneity to human phenotypes.Semantic proximity Read ↗

Pancreatic β-cell heterogeneity in health and diabetes: classes, sources, and subtypes.Semantic proximity Read ↗

Adherent reformed islets: a long-term primary cell-based platform for exploring mouse and human islet biologySemantic proximity Read ↗

Mapping histologic and functional maturation of human endocrine pancreas across early postnatal periodsSemantic proximity Read ↗

Comprehensive Characterization of Islet Remodeling in Development and in Diabetes Using Mass CytometrySemantic proximity Read ↗

Illuminating the complete ß-cell mass of the human pancreas - signifying a new view on the islets of LangerhansSemantic proximity Read ↗

Expansion and Differentiation of Adult Human Pancreas-Derived Progenitor Cells into Functional Islet-Like OrganoidsSemantic proximity Read ↗

Single cell and spatial characterization of the human pancreas reveals drivers of beta cell dysfunction in cystic fibrosisSemantic proximity Read ↗

Spatial and functional mapping of the human pancreas reveals endocrine and exocrine cell states in health and metabolic diseaseSemantic proximity Read ↗

Mesodermal-niche interactions direct specification and differentiation of pancreatic islet cells in human multilineage organoidsSemantic proximity Read ↗

Advances in pancreatic islet monolayer culture on glass surfaces enable super-resolution microscopy and insights into beta cell ciliogenesis and proliferation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.