Article

Single cell and spatial characterization of the human pancreas reveals drivers of beta cell dysfunction in cystic fibrosis

2025-12-16

Abstract excerpt

Cystic fibrosis (CF) causes severely damaged pancreas morphology and results in high rates of cystic fibrosis-related diabetes (CFRD), but the cellular pathways and regulatory programs driving CFRD pathogenesis in the pancreas are not understood. In this study, we performed single cell multiomic and spatial profiling of 2.04M cells in the pancreas from 23 non-disease and CF donors and defined regulatory programs a...

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Literature Corpus work: 9c16db3a-9859-5b89-be43-514dee485023
DOI: 10.64898/2025.12.14.694120

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