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Article

Global computational alignment of tumor and cell line transcriptional profiles

4 Jan 2021

Abstract excerpt

Cell lines are key tools for preclinical cancer research, but it remains unclear how well they represent patient tumor samples. Direct comparisons of tumor and cell line transcriptional profiles are complicated by several factors, including the variable presence of normal cells in tumor samples. We thus develop an unsupervised alignment method (Celligner) and apply it to integrate several large-scale cell line...

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PMID: 33397959
DOI: 10.1038/s41467-020-20294-x

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