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Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types

8 Aug 2019

Abstract excerpt

Cancer cell lines are a cornerstone of cancer research but previous studies have shown that not all cell lines are equal in their ability to model primary tumors. Here we present a comprehensive pan-cancer analysis utilizing transcriptomic profiles from The Cancer Genome Atlas and the Cancer Cell Line Encyclopedia to evaluate cell lines as models of primary tumors across 22 tumor types. We perform correlation...

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PMID: 31395879
DOI: 10.1038/s41467-019-11415-2

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