CTDPathSim: Cell line-tumor deconvoluted pathway-based similarity in the context of precision medicine in cancer ^*

Abstract excerpt

<h4>ABSTRACT</h4> In cancer research and drug development, human tumor-derived cell lines are used as popular model for cancer patients to evaluate the biological functions of genes, drug efficacy, side-effects, and drug metabolism. Using these cell lines, the functional relationship between genes and drug response and prediction of drug response based on genomic and chemical features have been studied. Knowing t...

Topics

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• Bioinformatics and Genomic Networks
• Cancer Genomics and Diagnostics
• Colorectal Cancer Treatments and Studies
• Gene expression and cancer classification
• Pancreatic and Hepatic Oncology Research

Identifiers and source

Literature Corpus work

d2cd58ba-73c4-51a5-a185-209f531f469d

DOI

10.1101/2020.06.13.149666