A comprehensive transcriptional portrait of human cancer cell lines.

doi:10.1038/nbt.3080

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Article

A comprehensive transcriptional portrait of human cancer cell lines.

Nature biotechnology - 1 Mar 2015

Klijn Christiaan, Durinck Steffen, Stawiski Eric W, Haverty Peter M, Jiang Zhaoshi, Liu Hanbin, Degenhardt Jeremiah, Mayba Oleg, Gnad Florian, Liu Jinfeng, Pau Gregoire, Reeder Jens, Cao Yi, Mukhyala Kiran, Selvaraj Suresh K, Yu Mamie, Zynda Gregory J, Brauer Matthew J, Wu Thomas D, Gentleman Robert C, Manning Gerard, Yauch Robert L, Bourgon Richard, Stokoe David, Modrusan Zora, Neve Richard M, de Sauvage Frederic J, Settleman Jeffrey, Seshagiri Somasekar, Zhang Zemin

Abstract excerpt

Tumor-derived cell lines have served as vital models to advance our understanding of oncogene function and therapeutic responses. Although substantial effort has been made to define the genomic constitution of cancer cell line panels, the transcriptome remains understudied. Here we describe RNA sequencing and single-nucleotide polymorphism (SNP) array analysis of 675 human cancer cell lines. We report...

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PMID: 25485619
DOI: 10.1038/nbt.3080

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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