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Article

Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH.

Nature communications - 4 Jan 2021

Dong Jinrui, Viswanathan Sivakumar, Adami Eleonora, Singh Brijesh K, Chothani Sonia P, Ng Benjamin, Lim Wei Wen, Zhou Jin, Tripathi Madhulika, Ko Nicole S J, Shekeran Shamini G, Tan Jessie, Lim Sze Yun, Wang Mao, Lio Pei Min, Yen Paul M, Schafer Sebastian, Cook Stuart A, Widjaja Anissa A

Abstract excerpt

IL11 is important for fibrosis in non-alcoholic steatohepatitis (NASH) but its role beyond the stroma in liver disease is unclear. Here, we investigate the role of IL11 in hepatocyte lipotoxicity. Hepatocytes highly express IL11RA and secrete IL11 in response to lipid loading. Autocrine IL11 activity causes hepatocyte death through NOX4-derived ROS, activation of ERK, JNK and caspase-3, impaired mitochondrial...

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Identifiers

PMID: 33397952
DOI: 10.1038/s41467-020-20303-z
PMCID: PMC7782504

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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