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Article

TLR9 in MAFLD and NASH: At the Intersection of Inflammation and Metabolism

29 Jan 2021

Abstract excerpt

Toll-Like Receptor 9 (TLR9) is an ancient receptor integral to the primordial functions of inflammation and metabolism. TLR9 functions to regulate homeostasis in a healthy system under acute stress. The literature supports that overactivation of TLR9 under the chronic stress of obesity is a critical driver of the pathogenesis of NASH and NASH-associated fibrosis. Research has focused on the core contributions of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33584545
DOI: 10.3389/fendo.2020.613639

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