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Article

Regulation of Hepatic Stellate Cell Phenotypes in Metabolic Dysfunction-Associated Steatohepatitis.

Gastroenterology - 1 Oct 2025

Kisseleva Tatiana, Ganguly Souradipta, Murad Rabi, Wang Allen, Brenner David A

Abstract excerpt

Hepatic stellate cells (HSCs) play a crucial role in the pathogenesis of liver fibrosis in metabolic dysfunction-associated steatohepatitis (MASH), a condition characterized by excessive fat accumulation in the hepatocytes, unrelated to alcohol consumption. In a healthy liver, HSCs are quiescent, store vitamin A, and function as pericytes. However, in response to liver injury and inflammation, HSCs become...

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Identifiers

PMID: 40120772
DOI: 10.1053/j.gastro.2025.03.010
PMCID: PMC12416914

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