Article
Single-molecule analysis reveals widespread structural variation in multiple myeloma.
Proceedings of the National Academy of Sciences of the United States of America - 23 Jun 2015
Gupta Aditya, Place Michael, Goldstein Steven, Sarkar Deepayan, Zhou Shiguo, Potamousis Konstantinos, Kim Jaehyup, Flanagan Claire, Li Yang, Newton Michael A, Callander Natalie S, Hematti Peiman, Bresnick Emery H, Ma Jian, Asimakopoulos Fotis, Schwartz David C
Abstract excerpt
Multiple myeloma (MM), a malignancy of plasma cells, is characterized by widespread genomic heterogeneity and, consequently, differences in disease progression and drug response. Although recent large-scale sequencing studies have greatly improved our understanding of MM genomes, our knowledge about genomic structural variation in MM is attenuated due to the limitations of commonly used sequencing approaches. In...
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