Article
Helix-Loop-Helix Factor Id3 (Inhibitor of Differentiation 3): A Novel Regulator of Hyaluronan-Mediated Adipose Tissue Inflammation.
Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 2021
Misiou Angelina, Garmey James C, Hensien Jack M, Harmon Daniel B, Osinski Victoria, McSkimming Chantel, Marshall Melissa A, Fischer Jens W, Grandoch Maria, McNamara Coleen A
Abstract excerpt
OBJECTIVE: The aim of this study was to unravel mechanisms whereby deficiency of the transcription factor Id3 (inhibitor of differentiation 3) leads to metabolic dysfunction in visceral obesity. We investigated the impact of loss of Id3 on hyaluronic acid (HA) production by the 3 HAS isoenzymes (HA synthases; -1, -2, and -3) and on obesity-induced adipose tissue (AT) accumulation of proinflammatory B cells....
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