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Article

Deletion of Hyaluronan Synthase 3 Inhibits Neointimal Hyperplasia in Mice.

Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 2016

Kiene Lena S, Homann Susanne, Suvorava Tatsiana, Rabausch Berit, Müller Julia, Kojda Georg, Kretschmer Inga, Twarock Sören, Dai Guang, Deenen René, Hartwig Sonja, Lehr Stefan, Köhrer Karl, Savani Rashmin C, Grandoch Maria, Fischer Jens W

Abstract excerpt

OBJECTIVE: Hyaluronan (HA) is a polymeric glucosaminoglycan that forms a provisional extracellular matrix in diseased vessels. HA is synthesized by 3 different HA synthases (HAS1, HAS2, and HAS3). Aim of this study was to unravel the role of the HAS3 isoenzyme during experimental neointimal hyperplasia. APPROACH AND RESULTS: Neointimal hyperplasia was induced in Has3-deficient mice by ligation of the carotid...

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Source

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Identifiers

PMID: 26586662
DOI: 10.1161/ATVBAHA.115.306607
PMCID: PMC5222548

Genes

HAS3
HAS1
HAS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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