Article

HOXB13 suppresses <i>de novo</i> lipogenesis through HDAC3-mediated epigenetic reprogramming

2021-10-05

Abstract excerpt

<h4>ABSTRACT</h4> HOXB13, a homeodomain transcription factor, critically regulates androgen receptor (AR) function and promotes androgen-dependent prostate cancer (PCa) growth. However, the functions of HOXB13 in an AR-independent context remain elusive. Here we report an essential role of HOXB13 in directly suppressing lipogenic transcriptional programs in both AR-positive and -negative PCa cells. The MEIS domai...

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Literature Corpus work: 2fbcb9a1-7498-51be-b3f8-be745d3a265d
DOI: 10.1101/2021.10.04.463081

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