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Article

Loss of Hdac3 in osteoprogenitors increases bone expression of osteoprotegerin, improving systemic insulin sensitivity.

Journal of cellular physiology - 1 Apr 2018

McGee-Lawrence Meghan E, Pierce Jessica L, Yu Kanglun, Culpepper Natasha R, Bradley Elizabeth W, Westendorf Jennifer J

Abstract excerpt

Type 2 diabetes is an emerging global health epidemic. Foundations for new therapies are arising from understanding interactions between body systems. Bone-derived factors that reduce RANKL (receptor activator of NF-kappa B ligand) signaling in the liver may prevent insulin resistance and the onset of type 2 diabetes. Here we demonstrate that deletion of the epigenetic regulator, Hdac3, in Osx1-expressing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28840938
DOI: 10.1002/jcp.26148
PMCID: PMC5741476

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