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Article

The Interplay Between Titin, Polygenic Risk, and Modifiable Cardiovascular Risk Factors in Atrial Fibrillation.

The Canadian journal of cardiology - 1 Jun 2021

Huang Kate, Trinder Mark, Roston Thomas M, Laksman Zachary W, Brunham Liam R

Abstract excerpt

BACKGROUND: Common and rare variants, including those in the gene for the cardiac structural protein titin (TTN), have been implicated in the risk of developing atrial fibrillation (AF). However, the effect of genetic variants on risk of AF compared with established modifiable risk factors is unclear. The objective of this study was to evaluate the risk of AF and associated cardiovascular complications in TTN...

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PMID: 33373724
DOI: 10.1016/j.cjca.2020.12.024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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