How Does Genetic Susceptibility Impact the Effectiveness of AF Ablation?

Abstract excerpt

Atrial fibrillation (AF) is a prevalent cardiac arrhythmia treated increasingly with catheter ablation, yet recurrence rates remain high. Genetic factors contribute to both AF susceptibility and response to therapy. This review summarises evidence on how common AF-associated variants, polygenic risk scores and rare monogenic variants influence ablation outcomes. Common single-nucleotide polymorphisms at loci such...

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