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Article

Titin truncating variants, cardiovascular risk factors and the risk of atrial fibrillation and heart failure.

Nature cardiovascular research - 1 Aug 2024

Shetty Naman S, Gaonkar Mokshad, Pampana Akhil, Patel Nirav, Li Peng, Arora Garima, Arora Pankaj

Abstract excerpt

High-proportion spliced-in (hiPSI) titin truncating variant (TTNtv) carriers have a higher risk of atrial fibrillation and heart failure1. However, the role of cardiovascular risk factors in modifying the risk of atrial fibrillation and heart failure attributed to hiPSI TTNtv carriers is unknown. Here, we investigate the role of cardiovascular risk, quantified using the pooled cohort equations (PCEs), in...

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Identifiers

PMID: 39196037
DOI: 10.1038/s44161-024-00511-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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