Article
Genome-wide Study of Atrial Fibrillation Identifies Seven Risk Loci and Highlights Biological Pathways and Regulatory Elements Involved in Cardiac Development.
American journal of human genetics - 4 Jan 2018
Nielsen Jonas B, Fritsche Lars G, Zhou Wei, Teslovich Tanya M, Holmen Oddgeir L, Gustafsson Stefan, Gabrielsen Maiken E, Schmidt Ellen M, Beaumont Robin, Wolford Brooke N, Lin Maoxuan, Brummett Chad M, Preuss Michael H, Refsgaard Lena, Bottinger Erwin P, Graham Sarah E, Surakka Ida, Chu Yunhan, Skogholt Anne Heidi, Dalen Håvard, Boyle Alan P, Oral Hakan, Herron Todd J, Kitzman Jacob, Jalife José, Svendsen Jesper H, Olesen Morten S, Njølstad Inger, Løchen Maja-Lisa, Baras Aris, Gottesman Omri, Marcketta Anthony, O'Dushlaine Colm, Ritchie Marylyn D, Wilsgaard Tom, Loos Ruth J F, Frayling Timothy M, Boehnke Michael, Ingelsson Erik, Carey David J, Dewey Frederick E, Kang Hyun M, Abecasis Gonçalo R, Hveem Kristian, Willer Cristen J
Abstract excerpt
Atrial fibrillation (AF) is a common cardiac arrhythmia and a major risk factor for stroke, heart failure, and premature death. The pathogenesis of AF remains poorly understood, which contributes to the current lack of highly effective treatments. To understand the genetic variation and biology underlying AF, we undertook a genome-wide association study (GWAS) of 6,337 AF individuals and 61,607 AF-free...
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