Article
Association Between Titin Loss-of-Function Variants and Early-Onset Atrial Fibrillation.
JAMA - 11 Dec 2018
Choi Seung Hoan, Weng Lu-Chen, Roselli Carolina, Lin Honghuang, Haggerty Christopher M, Shoemaker M Benjamin, Barnard John, Arking Dan E, Chasman Daniel I, Albert Christine M, Chaffin Mark, Tucker Nathan R, Smith Jonathan D, Gupta Namrata, Gabriel Stacey, Margolin Lauren, Shea Marisa A, Shaffer Christian M, Yoneda Zachary T, Boerwinkle Eric, Smith Nicholas L, Silverman Edwin K, Redline Susan, Vasan Ramachandran S, Burchard Esteban G, Gogarten Stephanie M, Laurie Cecelia, Blackwell Thomas W, Abecasis Gonçalo, Carey David J, Fornwalt Brandon K, Smelser Diane T, Baras Aris, Dewey Frederick E, Jaquish Cashell E, Papanicolaou George J, Sotoodehnia Nona, Van Wagoner David R, Psaty Bruce M, Kathiresan Sekar, Darbar Dawood, Alonso Alvaro, Heckbert Susan R, Chung Mina K, Roden Dan M, Benjamin Emelia J, Murray Michael F, Lunetta Kathryn L, Lubitz Steven A, Ellinor Patrick T
Abstract excerpt
Importance: Atrial fibrillation (AF) is the most common arrhythmia affecting 1% of the population. Young individuals with AF have a strong genetic association with the disease, but the mechanisms remain incompletely understood. Objective: To perform large-scale whole-genome sequencing to identify genetic variants related to AF. Design, Setting, and Participants: The National Heart, Lung, and Blood Institute's...
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