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Article

STAT3 and p53: Dual Target for Cancer Therapy

21 Dec 2020

Abstract excerpt

The tumor suppressor p53 is considered the "guardian of the genome" that can protect cells against cancer by inducing cell cycle arrest followed by cell death. However, STAT3 is constitutively activated in several human cancers and plays crucial roles in promoting cancer cell proliferation and survival. Hence, STAT3 and p53 have opposing roles in cellular pathway regulation, as activation of STAT3 upregulates the...

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PMID: 33371351
DOI: 10.3390/biomedicines8120637

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