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STAT3 inhibitor STAT-IN-12 induces apoptosis in mutant-p53 MDA-MB-435 and MDA-MB-231 breast cancer cell lines.

Molecular biology reports - 17 Apr 2026

Özdemi̇r Deniz, Baydas Gıyasettin, Özden Özkan, Fidaleo Marco, Ağca Can Ali

Abstract excerpt

BACKGROUND: p53 restricts tumorigenesis by eliminating damaged cells, whereas constitutively active STAT3 promotes cancer cell survival and proliferation. Their opposing functions, often reinforced by p53 mutation, represent key cooperative drivers of malignant progression. Mutant p53 (mt-p53) further activates STAT3, thereby amplifying tumour aggressiveness. Mutant p53, exhibiting hundreds of different mutant...

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Identifiers

PMID: 41996011
DOI: 10.1007/s11033-026-11805-y

Genes

STAT3
MB
RTCA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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