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Article

STAT proteins as novel targets for cancer drug discovery

1 Oct 2004

Abstract excerpt

Signal transducer and activator of transcription (STAT) proteins are latent cytoplasmic transcription factors that were discovered in the context of cytokine and growth factor signalling. Normal STAT signalling is tightly controlled with finite kinetics, which is in keeping with standard cellular responses. However, persistent STAT activation has also been observed and is frequently associated with malignant...

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PMID: 15469392
DOI: 10.1517/14728222.8.5.409

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