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Article

The Multifaced Role of STAT3 in Cancer and Its Implication for Anticancer Therapy

9 Jan 2021

Abstract excerpt

Signal transducer and activator of transcription (STAT) 3 is one of the most complex regulators of transcription. Constitutive activation of STAT3 has been reported in many types of tumors and depends on mechanisms such as hyperactivation of receptors for pro-oncogenic cytokines and growth factors, loss of negative regulation, and excessive cytokine stimulation. In contrast, somatic STAT3 mutations are less...

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PMID: 33435349
DOI: 10.3390/ijms22020603

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