Article

Alemtuzumab mediates T-regulatory response via macrophagal CD23.

2020-05-11

Abstract excerpt

<h4>Background: </h4> Alemtuzumab (ALM) effectively prevents multiple sclerosis (MS) relapses. It causes lymphocytic depletion with subsequent enhancement of T-regulatory cell population. Direct administration of ALM to T-cells causes cytolysis. However, the T-cells may be indirectly affected by myeloid cells, which are resistant to ALM cytotoxicity. Does ALM modulate monocytes? Does the cross-talk between expose...

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Literature Corpus work: 8d028223-157a-528a-9914-9050f06e6666
DOI: 10.21203/rs.3.rs-27301/v1

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